Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor.

@article{Gyobu2004GenerationAT,
  title={Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor.},
  author={Hiroshi Gyobu and Takemasa Tsuji and Yoshinori Suzuki and Takayuki Ohkuri and Kenji Chamoto and Masahide Kuroki and Hiroyuki Miyoshi and You Kawarada and Hiroyuki Katoh and Tsuguhide Takeshima and Takashi Nishimura},
  journal={Cancer research},
  year={2004},
  volume={64 4},
  pages={1490-5}
}
CD4+ Th cells, in particular IFN-gamma-producing Th1 cells, play a critical role in the activation and maintenance of Tc1 cells that are essential for tumor eradication. Here, we report the generation of artificial tumor-specific Th1 and Tc1 cells from nonspecifically activated T cells using a lentiviral transduction system. Anti-CD3-activated T cells from healthy human donors were transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor gene composed of single-chain… CONTINUE READING

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