Generation and study of the strains of streptomycetes - heterologous hosts for production of moenomycin.

@article{Lopatniuk2014GenerationAS,
  title={Generation and study of the strains of streptomycetes - heterologous hosts for production of moenomycin.},
  author={M Lopatniuk and Bohdan Ostash and Andriy Luzhetskyy and Suzanne Walker and Victor Fedorenko},
  journal={Russian journal of genetics},
  year={2014},
  volume={50 4},
  pages={360-365}
}
Moenomycins (Mm) are family of phosphoglycolipid natural products that is considered a blueprint to develop new class of antibiotics. The natural Mm producer, Streptomyces ghanaensis (ATCC14672), produces very low amounts of moenomycin, fueling the investigations on genetic approaches to improve its titers. Heterologous expression of moenomycin biosynthesis gene cluster (moe) would be one of the ways to reach this goal. Here we report the generation of a number of novel heterologous… CONTINUE READING

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