Generation and propagation of radical reactions on proteins.

  title={Generation and propagation of radical reactions on proteins.},
  author={C L Hawkins and Michael J Davies},
  journal={Biochimica et biophysica acta},
  volume={1504 2-3},
The oxidation of proteins by free radicals is thought to play a major role in many oxidative processes within cells and is implicated in a number of human diseases as well as ageing. This review summarises information on the formation of radicals on peptides and proteins and how radical damage may be propagated and transferred within protein structures. The emphasis of this article is primarily on the deleterious actions of radicals generated on proteins, and their mechanisms of action, rather… CONTINUE READING