Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice.

@article{Gomeza2001GenerationAP,
  title={Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice.},
  author={Jes{\'u}s Gomeza and Lei Zhang and Evi Kostenis and Christian C. Felder and Frank P. Bymaster and Joshua Brodkin and Harlan E. Shannon and Bing Xia and Alokesh Duttaroy and Chu Xia Deng and Juergen Wess},
  journal={Life sciences},
  year={2001},
  volume={68 22-23},
  pages={
          2457-66
        }
}
Muscarinic acetylcholine receptors (M1-M5) play important roles in the modulation of many key functions of the central and peripheral nervous system. To explore the physiological roles of the two Gi-coupled muscarinic receptors, we disrupted the M2 and M4 receptor genes in mice by using a gene targeting strategy. Pharmacological and behavioral analysis of the resulting mutant mice showed that the M2 receptor subtype is critically involved in mediating three of the most striking central… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…