Generation and metabolism of bioactive sphingosine-1-phosphate.

  title={Generation and metabolism of bioactive sphingosine-1-phosphate.},
  author={Herv{\'e} Le Stunff and Sheldon Milstien and Sarah Spiegel},
  journal={Journal of cellular biochemistry},
  volume={92 5},
Sphingosine-1-phosphate (S1P) is a bioactive lysosphingophospholipid that has been implicated in the regulation of vital biological processes. Abundant evidence indicates that S1P acts as both an intracellular messenger and an extracellular ligand for a family of five specific G protein-coupled S1P receptors (S1PRs). Cellular levels of S1P are tightly regulated in a spatio-temporal manner through its synthesis catalyzed by sphingosine kinases (SphKs) and degradation by S1P lyase (SPL) and… CONTINUE READING