Generation and functional characterization of specific receptor inhibitors based on an analysis of the VEGFR-2 activation mechanism

@inproceedings{Giese2012GenerationAF,
  title={Generation and functional characterization of specific receptor inhibitors based on an analysis of the VEGFR-2 activation mechanism},
  author={Alexandra L. Giese},
  year={2012}
}
Angiogenesis, the formation of new blood vessels from preexisting vasculature, mainly occurs during embryonic development. In the adult it takes place in the female reproductive system and during wound healing. Unregulated angiogenesis is associated with various diseases such as atherosclerosis, retinopathies, lymphoproliferative or rheumatoid disease, and cancer. Tumor neovascularization enables cancer cells to enter the blood circulation and to metastasize to other organs and is a hallmark of… CONTINUE READING

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