Generation and function of astroglial lipoproteins from Niemann-Pick type C1-deficient mice.

@article{Karten2005GenerationAF,
  title={Generation and function of astroglial lipoproteins from Niemann-Pick type C1-deficient mice.},
  author={Barbara Karten and Hideki Hayashi and Gordon A. Francis and Robert B. Campenot and Dennis E. Vance and Jean E. Vance},
  journal={The Biochemical journal},
  year={2005},
  volume={387 Pt 3},
  pages={779-88}
}
NPC (Niemann-Pick type C) disease is a progressive neurological disorder characterized by defects in intracellular cholesterol trafficking, accumulation of cholesterol in the endosomal system and impaired cholesterol homoeostasis. Although these alterations appear to occur in all NPC1-deficient cell types, the consequences are most profound in the nervous system. Since glial cells are important mediators of brain cholesterol homoeostasis, we proposed that defective generation and/or function of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…