Generation and development of RNA ligase ribozymes with modular architecture through "design and selection".


In vitro selection with long random RNA libraries has been used as a powerful method to generate novel functional RNAs, although it often requires laborious structural analysis of isolated RNA molecules. Rational RNA design is an attractive alternative to avoid this laborious step, but rational design of catalytic modules is still a challenging task. A… (More)
DOI: 10.3390/molecules15095850

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