Generation and characterization of mouse basophils from bone marrow and purification of basophils from spleen.

@article{Yoshimoto2012GenerationAC,
  title={Generation and characterization of mouse basophils from bone marrow and purification of basophils from spleen.},
  author={Tomohiro Yoshimoto and Kenji Nakanishi},
  journal={Current protocols in immunology},
  year={2012},
  volume={Chapter 3},
  pages={
          Unit 3.24
        }
}
Basophils are rare circulating granulocytes that originate from progenitor cells in the bone marrow and have been considered important effector cells in IgE-mediated allergic inflammation. Basophils constitute <1% of blood leukocytes and are usually absent or present only in small numbers in tissues. They may, however, be recruited to inflammatory sites when an antigen is present and contribute immediately to hypersensitivity reactions. Basophils can therefore serve as primary effector cells in… CONTINUE READING

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