Generation and characterization of monoclonal antibodies reactive with human B lymphocytes.

@article{Mittler1983GenerationAC,
  title={Generation and characterization of monoclonal antibodies reactive with human B lymphocytes.},
  author={Robert S. Mittler and Mary Anne Talle and Kevin Carpenter and Patricia E. Rao and Gideon Goldstein},
  journal={Journal of immunology},
  year={1983},
  volume={131 4},
  pages={1754-61}
}
Four novel monoclonal antibodies directed at determinants on human B lymphocytes were produced and characterized by flow cytometry using indirect immunofluorescence analysis. The antibodies, OKB1, OKB2, OKB4, and OKB7, define antigens not previously described on human B lymphocytes using B cell reactive monoclonal antibodies or standard B cell phenotypic markers. OKB4 [immunoglobulin M (IgM)] and OKB7 (IgG2a) were reactive with greater than 95% of all surface membrane immunoglobulin positive… CONTINUE READING

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