Generation and characterization of monoclonal antibodies against multiple epitopes on the C-terminal half of envelope gp46 of human T-cell leukemia virus type-I (HTLV-I).

@article{Tanaka1990GenerationAC,
  title={Generation and characterization of monoclonal antibodies against multiple epitopes on the C-terminal half of envelope gp46 of human T-cell leukemia virus type-I (HTLV-I).},
  author={Yoshio Tanaka and Makiko Yasumoto and Hiroshi Nyunoya and Teru Ogura and Masahiro Kikuchi and Kunitada Shimotohno and Hiroshi Shiraki and Noriyuki Kuroda and Hisatoshi Shida and Hideki Tozawa},
  journal={International journal of cancer},
  year={1990},
  volume={46 4},
  pages={675-81}
}
In order to study the antigenicity of envelope 46 kDa glycoprotein (gp46) of human T-cell leukemia virus type-I (HTLV-1), we have generated monoclonal anti-gp46 antibodies (MAbs), REY-7, REY-11, REY-16, REY-30, MET-2 and MET-3 from rats and mice. Immunoblot and immunofluorescence assays showed that these MAbs recognize gp46 and its related antigens, and specifically stained HTLV-I-bearing cells. All MAbs reacted with a recombinant gp46 antigen, N147, expressing the 147 amino acids in the C… CONTINUE READING

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