Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

Abstract

mAb to murine TNF (MuTNF) were produced after immunization of Armenian hamsters with purified, Escherichia coli-derived rMuTNF-alpha. Antibody produced from clone TN3-19.12, was purified and was found to inhibit 100% of the lytic activity of either recombinant or natural MuTNF-alpha at an antibody input of 25 ng/U. TN3-19.12 also inhibited all the lytic… (More)

Topics

  • Presentations referencing similar topics