Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice

  title={Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice},
  author={Samantha L. Hoopes and A. Gruzdev and M. Edin and J. Graves and J. Bradbury and G. Flake and F. Lih and L. Degraff and D. Zeldin},
  journal={PLoS ONE},
  • Samantha L. Hoopes, A. Gruzdev, +6 authors D. Zeldin
  • Published 2017
  • Chemistry, Medicine
  • PLoS ONE
  • Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation. Epoxide hydrolases metabolize EETs to their corresponding diols (dihydroxyeicosatrienoic acids; DHETs) which are biologically less active. Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and… CONTINUE READING
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