Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.

@article{Yeh2002GenerationAC,
  title={Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.},
  author={Shuyuan Yeh and Meng-Yin Tsai and Qingquan Xu and Xiao-min Mu and Henry A. Lardy and Ko-en Huang and Hank M Lin and S Yeh and Saleh Altuwaijri and Xinchang Zhou and Ligang Xing and Brendan F. Boyce and Mien-Chie Hung and Su Lei Zhang and Lin Gan and Chawnshang Chang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 21},
  pages={
          13498-503
        }
}
By using a cre-lox conditional knockout strategy, we report here the generation of androgen receptor knockout (ARKO) mice. Phenotype analysis shows that ARKO male mice have a female-like appearance and body weight. Their testes are 80% smaller and serum testosterone concentrations are lower than in wild-type (wt) mice. Spermatogenesis is arrested at pachytene spermatocytes. The number and size of adipocytes are also different between the wt and ARKO mice. Cancellous bone volumes of ARKO male… CONTINUE READING

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