Generation and characterization of a transgenic mouse with a functional human TSPY.

@article{Schubert2003GenerationAC,
  title={Generation and characterization of a transgenic mouse with a functional human TSPY.},
  author={Stephanie Schubert and Britta Skawran and Frank Dechend and Karim Nayernia and Andreas Meinhardt and Indrajit Nanda and Michael Schmid and Wolfgang Engel and Joerg Schmidtke},
  journal={Biology of reproduction},
  year={2003},
  volume={69 3},
  pages={968-75}
}
To generate an animal model that is suitable for the analysis of regulation and expression of human testis-specific protein, Y-encoded TSPY, a transgenic mouse line, TgTSPY9, harboring a complete structural human TSPY gene was generated. Fluorescence in situ hybridization and Southern analyses show that approximately 50 copies of the human TSPY transgene are integrated at a single chromosomal site that maps to the distal long arm of the Y chromosome. The transgene is correctly transcribed and… CONTINUE READING

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