Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure.

@article{Reid2010GenerationAC,
  title={Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure.},
  author={Bethany S Reid and Thomas D. Sargent and Trevor Williams},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2010},
  volume={239 4},
  pages={
          1188-96
        }
}
Previous studies identified Inka1 as a gene regulated by AP-2alpha in the neural crest required for craniofacial morphogenesis in fish and frog. Here, we extend the analysis of Inka1 function and regulation to the mouse by generating a LacZ knock-in allele. Inka1-LacZ allele expression occurs in the cephalic mesenchyme, heart, and paraxial mesoderm prior to E8.5. Subsequently, expression is observed in the migratory neural crest cells and their derivatives. Consistent with expression of Inka1… CONTINUE READING

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