Generation and characterization of a humanized bradykinin B1 receptor mouse.

@article{Hess2006GenerationAC,
  title={Generation and characterization of a humanized bradykinin B1 receptor mouse.},
  author={John F. Hess and Richard Z. Chen and Patricia J. Hey and Robert Breese and Ray Chang and Tsing-Bau Chen and Mark G Bock and Thomas Joesf Vogt and Douglas J. Pettibone},
  journal={Biological chemistry},
  year={2006},
  volume={387 2},
  pages={195-201}
}
Antagonists of the B1 bradykinin receptor (B1R), encoded by the BDKRB1 gene, offer the promise of novel therapeutic agents for inflammatory and neuropathic pain. However, the in vivo characterization of the pharmacodynamics of B1R antagonists is hindered by the low level of B1R expression in healthy tissue and the profound species selectivity exhibited by many compounds for the B1R. To circumvent these issues we generated two genetically engineered rodent models. The first is a transgenic rat… CONTINUE READING