Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor.

@article{Behdani2012GenerationAC,
  title={Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor.},
  author={Mahdi Behdani and S Zeinali and Hossein Khanahmad and Morteza Karimipour and Nader Asadzadeh and Keyhan Azadmanesh and Ali Reza Khabiri and Steve Schoonooghe and Mahdi Habibi Anbouhi and Gholamreza Hassanzadeh-Ghassabeh and Serge Muyldermans},
  journal={Molecular immunology},
  year={2012},
  volume={50 1-2},
  pages={35-41}
}
Vascular endothelial growth factor receptor-2 (VEGFR2) is an important tumor-associated receptor and blockade of the VEGF receptor signaling can lead to the inhibition of neovascularization and tumor metastasis. Nanobodies are the smallest intact antigen binding fragments derived from heavy chain-only antibodies occurring in camelids. Here, we describe the identification of a VEGFR2-specific Nanobody, named 3VGR19, from dromedaries immunized with a cell line expressing high levels of VEGFR2. We… CONTINUE READING