Generation and characterization of Tmeff2 mutant mice.

@article{Chen2012GenerationAC,
  title={Generation and characterization of Tmeff2 mutant mice.},
  author={Tian Rui Chen and Ping Wang and Liberty K Carroll and Ying-jiu Zhang and Bao-xia Han and Fan Wang},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={425 2},
  pages={
          189-94
        }
}
TMEFF2 is a single-transmembrane protein containing one EGF-like and two follistatin-like domains. Some studies implicated TMEFF2 as a tumor suppressor for prostate and other cancers, whereas others reported TMEFF2 functioning as a growth factor for neurons and other cells. To gain insights into the apparently conflicting roles of TMEFF2, we generated a null allele of Tmeff2 gene by replacing its first coding exon with human placental alkaline phosphatase cDNA (Tmeff2(PLAP)). Tmeff2(PLAP/PLAP… CONTINUE READING

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