Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.

@article{KowalczykQuintas2014GenerationAC,
  title={Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.},
  author={Christine Kowalczyk-Quintas and Laure Willen and Anh Thu Dang and Heidi Sarrasin and Aubry Tardivel and Katharina Hermes and Holm Schneider and Olivier Gaide and Olivier Donz{\'e} and Neil Kirby and Denis J Headon and Pascal Schneider},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 7},
  pages={4273-85}
}
Development of ectodermal appendages, such as hair, teeth, sweat glands, sebaceous glands, and mammary glands, requires the action of the TNF family ligand ectodysplasin A (EDA). Mutations of the X-linked EDA gene cause reduction or absence of many ectodermal appendages and have been identified as a cause of ectodermal dysplasia in humans, mice, dogs, and… CONTINUE READING