Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis.

@article{Tang2016GenerationAA,
  title={Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis.},
  author={Xiao-lei Tang and Shi-min Wu and Yan Qing Xie and Neng Song and Qing Guan and Chunhui Yuan and Xiang Zhou and Xiao-Lian Zhang},
  journal={The Journal of infection},
  year={2016},
  volume={72 5},
  pages={
          573-86
        }
}
The development of effective Mycobacterial antigen diagnostic reagents remains a high priority. Mannose-capped lipoarabinomannan (ManLAM) is a lipoglycan serving as a major cell wall component. ManLAM is also an early released antigen in the blood circulation system during Mycobacteria tuberculosis (M.tb) infection and is a perfect target antigen for TB diagnosis. In this study, ssDNA aptamers "antibodies" against ManLAM of the predominant clinical epidemic M.tb Beijing genotype strains were… CONTINUE READING