Generation and application of mammalian haploid embryonic stem cells.

@article{Bai2016GenerationAA,
  title={Generation and application of mammalian haploid embryonic stem cells.},
  author={Meizhu Bai and Yujie Wu and J Li},
  journal={Journal of internal medicine},
  year={2016},
  volume={280 3},
  pages={236-45}
}
Haploid cells contain one set of chromosomes and are amenable for genetic analyses. In mammals, haploidy exists only in gametes. An intriguing question is whether haploid cells can be derived from gametes. Recently, by application of haploid cell enrichment using fluorescence-activated cell sorting, stable haploid embryonic stem cells (haESCs) have been successfully derived from oocyte-derived parthenogenetic and sperm-derived androgenetic embryos from several species. Whilst both… CONTINUE READING