Generation, isolation, and engraftment of in vitro-derived human T cell progenitors.


T cells typically differentiate via a series of coordinated steps within the highly specialized microenvironment of the thymus. Traditionally, human T-lymphopoiesis in vitro has been studied using the hybrid human/mouse fetal thymic organ culture system. Pioneering work by McCune et al. devised a method to examine human T cell development in vivo in… (More)
DOI: 10.1007/978-1-62703-128-8_7


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