Generating specificity and diversity in the transcriptional response to hypoxia

  title={Generating specificity and diversity in the transcriptional response to hypoxia},
  author={Urban Lendahl and Kian Leong Lee and Henry Yang and Lorenz Poellinger},
  journal={Nature Reviews Genetics},
The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells. The hypoxic-sensitive regulation of gene expression allows information about the oxygen status to be converted into appropriate cellular responses. Although there is a core transcriptional pathway, the signalling cascade can be modified to allow diversity and specificity in the transcriptional output. In this Review, we discuss recent advances in our understanding of the mechanisms and factors that… CONTINUE READING
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