Generating mice with targeted mutations

@article{Capecchi2001GeneratingMW,
  title={Generating mice with targeted mutations},
  author={M. Capecchi},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={1086-1090}
}
  • M. Capecchi
  • Published 2001
  • Biology, Medicine
  • Nature Medicine
. We had an im- portant conceptual change early in our studies of the genetic complexities of hypertension. This was a shift from considering absence of gene function as a principal cause of disease (as is the case with the uncommon disease cystic fibrosis) to consid- ering the possibility that inherited quantitative variations (per- haps even normal variations) in gene expression might be more important in causing the complex common conditions. To in- vestigate this possibility experimentally… Expand
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