Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination

@inproceedings{Nicols2018GeneratingAR,
  title={Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination},
  author={Laura Nicol{\'a}s and Montserrat Cols and Jee Eun Choi and Jayanta Chaudhuri and Bao Vuong},
  booktitle={F1000Research},
  year={2018}
}
Adaptive immune responses require the generation of a diverse repertoire of immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of antigens. V(D)J recombination creates the primary Ig repertoire, which subsequently is modified by somatic hypermutation (SHM) and class switch recombination (CSR). SHM promotes Ig affinity maturation whereas CSR alters the effector function of the Ig. Both SHM and CSR require activation-induced cytidine deaminase (AID) to produce dU… CONTINUE READING