Generating Diverse Skeletons of Small Molecules Combinatorially
@article{Burke2003GeneratingDS, title={Generating Diverse Skeletons of Small Molecules Combinatorially}, author={M. Burke and E. Berger and S. Schreiber}, journal={Science}, year={2003}, volume={302}, pages={613 - 618} }
Lack of efficient access to collections of synthetic compounds that have skeletal diversity is a key bottleneck in the small-molecule discovery process. We report a synthesis strategy that involves transforming substrates with different appendages that pre-encode skeletal information, named σ elements, into products that have different skeletons with the use of common reaction conditions. With this approach, split-pool synthesis can be used to pre-encode skeletal diversity combinatorially and… CONTINUE READING
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