Generating Diverse Skeletons of Small Molecules Combinatorially

@article{Burke2003GeneratingDS,
  title={Generating Diverse Skeletons of Small Molecules Combinatorially},
  author={M. Burke and E. Berger and S. Schreiber},
  journal={Science},
  year={2003},
  volume={302},
  pages={613 - 618}
}
  • M. Burke, E. Berger, S. Schreiber
  • Published 2003
  • Chemistry, Medicine
  • Science
  • Lack of efficient access to collections of synthetic compounds that have skeletal diversity is a key bottleneck in the small-molecule discovery process. We report a synthesis strategy that involves transforming substrates with different appendages that pre-encode skeletal information, named σ elements, into products that have different skeletons with the use of common reaction conditions. With this approach, split-pool synthesis can be used to pre-encode skeletal diversity combinatorially and… CONTINUE READING
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