Generalized seizures induce c-fos protein(s) in mammalian neurons.

  title={Generalized seizures induce c-fos protein(s) in mammalian neurons.},
  author={Mike Dragunow and Harold A. Robertson},
  journal={Neuroscience letters},
  volume={82 2},
We have recently detected low basal levels of c-fos protein-like immunoreactivity in adult mammalian neurons. Here we report that generalized tonic-clonic seizures in mice are associated with a massive increase in c-fos protein-like immunoreactivity in the cingulate and piriform cortices and the dentate gyrus 1 h after injection of pentylenetetrazol. Midazolam, which prevented the pentylenetetrazol seizures also prevented the increase in c-fos protein-like immunoreactivity. These results… CONTINUE READING


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