Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

@article{Liston2004GeneralizedRT,
  title={Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.},
  author={Adrian Liston and Sylvie Lesage and Daniel H D Gray and Lorraine A O'reilly and Andreas Strasser and Aude M. Fahrer and Richard L. Boyd and Judith A Wilson and Alan G. Baxter and Elena M. Gallo and Gerald R Crabtree and Kaiman Peng and Susan R. Wilson and Christopher C. Goodnow},
  journal={Immunity},
  year={2004},
  volume={21 6},
  pages={817-30}
}
The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deletion in vivo that applies equally to Aire-induced organ-specific gene products in the thymic medulla and to systemic antigens expressed at high levels throughout the thymus and… CONTINUE READING
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