Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis.

@article{Depoortere2002GeneralizedLO,
  title={Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis.},
  author={Inge Depoortere and Theo Thijs and Theo Louis Peeters},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 8},
  pages={2011-9}
}
1. Inflammation may affect subpopulations of neurons of the myenteric plexus. 2. In the present study the effect of trinitrobenzene sulphonic acid (TNBS) induced colitis on nitrergic, purinergic and adrenergic inhibitory neurotransmission was studied as well as the consequences of the related changes on the response of 5-HT agonists using these… CONTINUE READING