Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.

@article{Charmandari2008GeneralizedGR,
  title={Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.},
  author={Evangelia Charmandari and Tomoshige Kino and Takamasa Ichijo and George P. Chrousos},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 5},
  pages={1563-72}
}
CONTEXT Primary generalized glucocorticoid resistance is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. We review the clinical aspects, molecular mechanisms, and implications of this disorder. EVIDENCE ACQUISITION We conducted a systematic review of the published, peer-reviewed medical literature using MEDLINE (1975 through February 2008) to identify original articles and reviews on this topic. EVIDENCE SYNTHESIS We have… CONTINUE READING
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