Generalized facilitated diffusion model for DNA-binding proteins with search and recognition states.

@article{Bauer2012GeneralizedFD,
  title={Generalized facilitated diffusion model for DNA-binding proteins with search and recognition states.},
  author={Maximilian Bauer and Ralf Metzler},
  journal={Biophysical journal},
  year={2012},
  volume={102 10},
  pages={2321-30}
}
Transcription factors (TFs) such as the lac repressor find their target sequence on DNA at remarkably high rates. In the established Berg-von Hippel model for this search process, the TF alternates between three-dimensional diffusion in the bulk solution and one-dimensional sliding along the DNA chain. To overcome the so-called speed-stability paradox, in similar models the TF was considered as being present in two conformations (search state and recognition state) between which it switches… CONTINUE READING
Highly Cited
This paper has 44 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
20 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Dynamical model of DNAprotein interaction: effect of protein charge distribution and mechanical properties

  • Florescu, A.-M, M. Joyeux
  • J. Chem. Phys. 131:105102
  • 2009

Facilitated diffusion in a crowded environment: from kinetics to stochastics

  • Y. Meroz, I. Eliazar, J. Klafter
  • J. Phys. A
  • 2009

Similar Papers

Loading similar papers…