Generalized Seizures Following Topical Lidocaine Administration During Circumcision

  title={Generalized Seizures Following Topical Lidocaine Administration During Circumcision},
  author={Massoud Rezvani and Yaron Finkelstein and Zulfukarali Verjee and Craig J. Railton and Gideon Koren},
  journal={Pediatric Drugs},
We report a case of neonatal seizures after lidocaine administration for circumcision. A 3-month-old male infant received an overdose as evidenced by toxic lidocaine levels and developed generalized seizures shortly after. Back extrapolation of the serum lidocaine concentration to time zero was used to determine the administered dose. The Naranjo scale was used to determine causation; probable causation was defined. Particular care must be taken to administer an appropriate dose of local… Expand
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  • C. Berde
  • Medicine
  • Anesthesia and analgesia
  • 1992
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