Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

@inproceedings{Harris2012GeneralizedLW,
  title={Generalized L{\'e}vy walks and the role of chemokines in migration of effector CD8+ T cells},
  author={Tajie H. Harris and Edward J. Banigan and David A. Christian and Christoph Konradt and Elia D. Tait Wojno and Kazumi Norose and Emma H Wilson and Beena John and Wolfgang Weninger and Andrew D Luster and Andrea J. Liu and Christopher A Hunter},
  booktitle={Nature},
  year={2012}
}
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the… CONTINUE READING
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