General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base.

@article{Streng1984GeneralTO,
  title={General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base.},
  author={W. Streng and S K Hsi and P E Helms and Hong-gen Tan},
  journal={Journal of pharmaceutical sciences},
  year={1984},
  volume={73 12},
  pages={1679-84}
}
The pH-solubility profile of a weak acid or base is shown to be a function of its pKsp, pKa, and uncharged species solubility. Equations are presented that can be used to calculate the solubility as a function of pH. These equations can also be used when there is added salt present. Experimental data was obtained in three cosolvent systems consisting of methanol-water and ethanol-water. Also, the effect of different acids on the solubility of a weak base is reported. A pronounced effect on the… CONTINUE READING