General survey of diabetic features of yellow KK mice.

  title={General survey of diabetic features of yellow KK mice.},
  author={H. Iwatsuka and Akio Shino and Z. Suzuoki},
  journal={Endocrinologia japonica},
  volume={17 1},
Yellow KK mice, carrying the yellow obese gene (Ay), developed marked adiposity and diabetic symptoms in comparison with their control littermates, black KK mice. The blood glucose and circulating insulin levels were increased progressively from 5 weeks of age in yellow KK mice. Age dependent alterlations were also observed in pancreas and kidney. Namely, degranulation and glycogen infiltration of B cells, first observed at 5 weeks of age, were followed by hypertrophy and central cavitation of… CONTINUE READING

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