General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.

@article{Ciccone1995GeneralRO,
  title={General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.},
  author={Ermanno 5 Ciccone and Daniela Pende and Luisa Nanni and Carlo Di Donato and Oriane Viale and Alberto Beretta and Massimo Vitale and Simona Sivori and Alessandro Moretta and Lorenzo Moretta},
  journal={International immunology},
  year={1995},
  volume={7 3},
  pages={393-400}
}
Some HLA-C alleles have been shown to exert a specific protective effect preventing target cells from lysis by groups of natural killer (NK) clones displaying a defined specificity. In this study, we analyzed whether class I-mediated protection is a more general phenomenon involving all NK cells. First, we utilized two anti-class I mAbs (6A4 of IgG1 isotype… CONTINUE READING