General principles of antibiotic tissue penetration.


It is well established that, at equilibrium, the concentrations of free drug on either side of a porous capillary are equal. However, the dynamic factors which operate on the way to achieving this equilibrium, while drug levels fluctuate in serum and extravascular sites, have been less well studied. This paper reviews some of the physical principles… (More)


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@article{Barza1985GeneralPO, title={General principles of antibiotic tissue penetration.}, author={Michael Barza and George J Cuchural}, journal={The Journal of antimicrobial chemotherapy}, year={1985}, volume={15 Suppl A}, pages={59-75} }