General paucity of genomic alteration and low tumor mutation burden in refractory and metastatic hepatoblastoma: comprehensive genomic profiling study.

Abstract

Hepatoblastoma (HBL) is a hepatic malignancy of infants and young children, which is often cured by combinations of surgery and chemotherapy. Management of refractory and metastatic HBL is challenging. Comprehensive genomic profiling was performed on 31 refractory and metastatic HBL using a hybrid-capture, adaptor ligation-based next-generation sequencing… (More)
DOI: 10.1016/j.humpath.2017.10.007

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@article{Lee2017GeneralPO, title={General paucity of genomic alteration and low tumor mutation burden in refractory and metastatic hepatoblastoma: comprehensive genomic profiling study.}, author={Hwajeong Lee and Tony El Jabbour and Sanaz Ainechi and Laurie M Gay and Julia A. Elvin and Jo-Anne Vergilio and James Suh and Shakti H. Ramkissoon and S. Machmud Ali and Alexa B. Schrock and David Fabrizio and Garrett M. Frampton and Tipu Nazeer and V. A. Miller and P. Stephens and Jeffrey S Ross}, journal={Human pathology}, year={2017}, volume={70}, pages={84-91} }