General obstetrics: A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study
@article{Shennan2006GeneralOA, title={General obstetrics: A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study}, author={Andrew H. Shennan and Sarah Crawshaw and Annette L Briley and Jennifer Hawken and Paul T. Seed and Griff Jones and Lucilla Poston}, journal={BJOG: An International Journal of Obstetrics \& Gynaecology}, year={2006}, volume={113} }
Objective To determine whether metronidazole reduces early preterm labour in asymptomatic women with positive vaginal fetal fibronectin (fFN) in the second trimester of pregnancy.
69 Citations
Additional antibiotic use and preterm birth among bacteriuric and nonbacteriuric pregnant women
- MedicineInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
- 2008
Clinical predictive factors for preterm birth in women with threatened preterm labour or preterm premature ruptured membranes?
- MedicineThe Australian & New Zealand journal of obstetrics & gynaecology
- 2009
Independent predictive factors of preterm delivery were evaluated using clinical data at hospitalisation by multivariate analysis to identify the most likely sources of maternal preterm birth complications.
Metronidazole Does Not Prevent Early Labor in High-Risk Women
- Medicine
- 2006
Infection, inflammatory response, or both are thought to have roles in initiating early labor and in women at high risk for preterm labor, the presence of infection or inflammatory response is a concern.
Qualitative cervicovaginal fluid β-hCG versus cervicovaginal fluid fetal fibronectin assessment in prediction of preterm labor in asymptomatic high risk women
- Medicine
- 2018
Qualitative β-hCG assessment in cervicovaginal fluid can be used as an alternative method to qualitative fFN assessment as it is a valid test, more available, and not expensive in prediction of PTL in asymptomatic high-risk patients.
Antibiotics for preventing preterm labour; An umbrella review
- Medicine
- 2014
The result of this umbrella review does not supports the use of antibiotics during pregnancy except when there is a clear evidence of infection with extreme caution, regular follow ups and monitoring of the patient.
Goals and strategies for prevention of preterm birth: an obstetric perspective.
- MedicinePediatric clinics of North America
- 2009
Bacterial Vaginosis Screening and Treatment in Pregnant Women.
- MedicineJournal of midwifery & women's health
- 2016
An overview of BV is provided, the evidence regarding screening and treating BV in pregnant women is reviewed, and treatment recommendations for pregnant women who have symptomatic BV are summarized.
Clinical trial of interconceptional antibiotics to prevent preterm birth: subgroup analyses and possible adverse antibiotic-microbial interaction.
- Medicine, BiologyAmerican journal of obstetrics and gynecology
- 2007
CERVICO-VAGINAL SWABS TO PREDICT PROM: A CASE STUDY
- Medicine
- 2013
There was a very high positive correlation between the incidence of a positive swab culture and preterm events, and it was found that the best time for a cervicovaginal swab was during the 3rd trimester, which is also the most commonly prevalent among all the microorganisms isolated.
References
SHOWING 1-10 OF 29 REFERENCES
Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomised, placebo controlled trial
- MedicineBritish journal of obstetrics and gynaecology
- 1997
Objective To ascertain whether metronidazole treatment of women with a heavy growth of Gardnerella vaginalis during mid‐pregnancy would reduce the risk of spontaneous preterm birth.
Fetal fibronectin test predicts delivery before 30 weeks of gestation in high risk women, but increases anxiety
- MedicineBJOG : an international journal of obstetrics and gynaecology
- 2005
Objective To assess efficacy of cervico‐vaginal fetal fibronectin as a predictor of spontaneous preterm birth in a high risk antenatal population, and to evaluate the psychological impact of fetal…
Metronidazole treatment of women with a positive fetal fibronectin test result.
- MedicineAmerican journal of obstetrics and gynecology
- 2001
In this subgroup analysis, women who were treated with metronidazole had a nonsignificant reduction in spontaneous preterm birth from 14.6% to 8.3%.
Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery
- MedicineUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
- 1998
To examine the potential value of routine measurement of cervical length in singleton pregnancies at 23 weeks of gestation in the prediction of the risk for early spontaneous preterm delivery.
Infection and prematurity and the role of preventive strategies.
- MedicineSeminars in neonatology : SN
- 2002
The evidence that infection is causally linked to premature birth is critically examined, as is the relationship between urogenital tract infection/colonization with microorganisms and the risk of preterm birth.
Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study.
- MedicineAmerican journal of obstetrics and gynecology
- 1994
Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review
- MedicineBMJ : British Medical Journal
- 2002
Cervicovaginal fetal fibronectin test is most accurate in predicting spontaneous preterm birth within 7-10 days of testing among women with symptoms of threatened pre term birth before advanced cervical dilatation.
Preterm labour--is bacterial vaginosis involved?
- Medicine, BiologySouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
- 2002
Metronidazole does not seem to reduce the prevalence of preterm labour when given for BV before 26 weeks' gestation, and analysis for maximum likelihood estimates for pre term labour identified only previous preterm Labour or midtrimester abortion as risk factors.
Randomized Clinical Trial of Metronidazole Plus Erythromycin to Prevent Spontaneous Preterm Delivery in Fetal Fibronectin–Positive Women
- MedicineObstetrics and gynecology
- 2003
Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis.
- MedicineAmerican journal of obstetrics and gynecology
- 2003
The screening of pregnant women who have bacterial vaginosis and who have had a previous preterm delivery and treatment with an oral regimen of longer duration can be justified on the basis of current evidence.