General obstetrics: A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study

  title={General obstetrics: A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study},
  author={Andrew H. Shennan and Sarah Crawshaw and Annette L Briley and Jennifer Hawken and Paul T. Seed and Griff Jones and Lucilla Poston},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
Objective  To determine whether metronidazole reduces early preterm labour in asymptomatic women with positive vaginal fetal fibronectin (fFN) in the second trimester of pregnancy. 

Additional antibiotic use and preterm birth among bacteriuric and nonbacteriuric pregnant women

Clinical predictive factors for preterm birth in women with threatened preterm labour or preterm premature ruptured membranes?

Independent predictive factors of preterm delivery were evaluated using clinical data at hospitalisation by multivariate analysis to identify the most likely sources of maternal preterm birth complications.

Metronidazole Does Not Prevent Early Labor in High-Risk Women

Infection, inflammatory response, or both are thought to have roles in initiating early labor and in women at high risk for preterm labor, the presence of infection or inflammatory response is a concern.

Qualitative cervicovaginal fluid β-hCG versus cervicovaginal fluid fetal fibronectin assessment in prediction of preterm labor in asymptomatic high risk women

Qualitative β-hCG assessment in cervicovaginal fluid can be used as an alternative method to qualitative fFN assessment as it is a valid test, more available, and not expensive in prediction of PTL in asymptomatic high-risk patients.

Antibiotics for preventing preterm labour; An umbrella review

The result of this umbrella review does not supports the use of antibiotics during pregnancy except when there is a clear evidence of infection with extreme caution, regular follow ups and monitoring of the patient.

Bacterial Vaginosis Screening and Treatment in Pregnant Women.

An overview of BV is provided, the evidence regarding screening and treating BV in pregnant women is reviewed, and treatment recommendations for pregnant women who have symptomatic BV are summarized.


There was a very high positive correlation between the incidence of a positive swab culture and preterm events, and it was found that the best time for a cervicovaginal swab was during the 3rd trimester, which is also the most commonly prevalent among all the microorganisms isolated.



Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomised, placebo controlled trial

Objective To ascertain whether metronidazole treatment of women with a heavy growth of Gardnerella vaginalis during mid‐pregnancy would reduce the risk of spontaneous preterm birth.

Fetal fibronectin test predicts delivery before 30 weeks of gestation in high risk women, but increases anxiety

Objective  To assess efficacy of cervico‐vaginal fetal fibronectin as a predictor of spontaneous preterm birth in a high risk antenatal population, and to evaluate the psychological impact of fetal

Metronidazole treatment of women with a positive fetal fibronectin test result.

In this subgroup analysis, women who were treated with metronidazole had a nonsignificant reduction in spontaneous preterm birth from 14.6% to 8.3%.

Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery

To examine the potential value of routine measurement of cervical length in singleton pregnancies at 23 weeks of gestation in the prediction of the risk for early spontaneous preterm delivery.

Infection and prematurity and the role of preventive strategies.

The evidence that infection is causally linked to premature birth is critically examined, as is the relationship between urogenital tract infection/colonization with microorganisms and the risk of preterm birth.

Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review

Cervicovaginal fetal fibronectin test is most accurate in predicting spontaneous preterm birth within 7-10 days of testing among women with symptoms of threatened pre term birth before advanced cervical dilatation.

Preterm labour--is bacterial vaginosis involved?

Metronidazole does not seem to reduce the prevalence of preterm labour when given for BV before 26 weeks' gestation, and analysis for maximum likelihood estimates for pre term labour identified only previous preterm Labour or midtrimester abortion as risk factors.

Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis.

The screening of pregnant women who have bacterial vaginosis and who have had a previous preterm delivery and treatment with an oral regimen of longer duration can be justified on the basis of current evidence.