General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

@article{Houghten1985GeneralMF,
  title={General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.},
  author={R. Houghten},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 15},
  pages={
          5131-5
        }
}
  • R. Houghten
  • Published 1985
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
A novel yet simple method is described that facilitates the synthesis of large numbers of peptides to the extent that the synthesis process need no longer be the limiting factor in many studies involving peptides. By using the methods described, 10-20 mg of 248 different 13-residue peptides representing single amino acid variants of a segment of the hemagglutinin protein (HA1) have been prepared and characterized in less than 4 weeks. Through examination of the binding of these analogs to… Expand
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