General mechanisms of metastasis.

  title={General mechanisms of metastasis.},
  author={Elisa C. Woodhouse and Rodrigo F. Chuaqui and Lance A. Liotta},
  volume={80 8 Suppl},
In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.