General anesthetics inhibit the nitrous-oxide-induced activation of corticotropin releasing factor containing neurons in rats.

@article{Sawamura2004GeneralAI,
  title={General anesthetics inhibit the nitrous-oxide-induced activation of corticotropin releasing factor containing neurons in rats.},
  author={Shigehito Sawamura and Mizuki Obara-Nawata and Kenji Takeda and Kazuo Hanaoka},
  journal={European journal of pharmacology},
  year={2004},
  volume={503 1-3},
  pages={49-53}
}
The activation of intracerebral corticotropin releasing factor (CRF) system is involved in nitrous oxide analgesia. We evaluated the effect of general anesthetics on nitrous-oxide-induced CRF activation and antinociception. Male Sprague-Dawley rats inhaled isoflurane (0%, 0.6%, 1.0% and 1.5%) or were administered with intravenous propofol (0, 0.1 and 0.2 mg/kg/min), with or without 75% nitrous oxide inhalation, for 90 min. The brain was fixed with fixative, and brain sections, including the… CONTINUE READING

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