Corpus ID: 20107937

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.

@article{Krasowski2001GeneralAP,
  title={General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.},
  author={Matthew D. Krasowski and Andrew Tobias Aveling Jenkins and Pamela S. Flood and Aisha Y Kung and Anton J. Hopfinger and Neil L. Harrison},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={297 1},
  pages={
          338-51
        }
}
  • Matthew D. Krasowski, Andrew Tobias Aveling Jenkins, +3 authors Neil L. Harrison
  • Published in
    The Journal of pharmacology…
    2001
  • Chemistry, Medicine
  • A series of 27 analogs of the general anesthetic propofol (2,6-diisopropylphenol) were examined for general anesthetic activity in Xenopus laevis tadpoles and for the ability to produce enhancement of submaximal GABA responses and/or direct activation at recombinant GABA(A) receptors. Fourteen of the propofol analogs produced loss of righting reflex in the tadpoles, whereas 13 were inactive as anesthetics. The same pattern of activity was noted with the actions of the compounds at the GABA(A… CONTINUE READING

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