General anesthesia improves fetal cerebral oxygenation without evidence of subsequent neuronal injury.

@article{McClaine2005GeneralAI,
  title={General anesthesia improves fetal cerebral oxygenation without evidence of subsequent neuronal injury.},
  author={Rebecca J. McClaine and Kenichiro Uemura and Sebastian G de la Fuente and Roberto J. Manson and John V. Booth and William D. White and Kurt A. Campbell and Deborah J. McClaine and Paul B Benni and W Steve Eubanks and James D. Reynolds},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2005},
  volume={25 8},
  pages={
          1060-9
        }
}
Anesthetic exposure during pregnancy is viewed as a relatively routine medical practice. However, recent rodent studies have suggested that common anesthetic agents can damage the developing brain. Here we assessed this claim in a higher order species by exposing previously instrumented near-term pregnant sheep at gestational day 122 (+/-1) to a combination of midazolam, sodium thiopental, and isoflurane at clinically relevant doses and means of anesthetic delivery (i.e., active ventilation… CONTINUE READING

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Developmental anesthetic neurotoxicity: from animals to humans?

  • Journal of Anesthesia
  • 2013
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[Effects of general anaesthetics on the developing brain].

  • Annales francaises d'anesthesie et de reanimation
  • 2010
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