General and specific lipid-protein interactions in Na,K-ATPase.

  title={General and specific lipid-protein interactions in Na,K-ATPase.},
  author={Flemming Cornelius and Michael Habeck and Ryuta Kanai and Chikashi Toyoshima and Steven J D Karlish},
  journal={Biochimica et biophysica acta},
  volume={1848 9},
The molecular activity of Na,K-ATPase and other P2 ATPases like Ca(2+)-ATPase is influenced by the lipid environment via both general (physical) and specific (chemical) interactions. Whereas the general effects of bilayer structure on membrane protein function are fairly well described and understood, the importance of the specific interactions has only been realized within the last decade due particularly to the growing field of membrane protein crystallization, which has shed new light on the… CONTINUE READING


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