General and efficient indole syntheses based on catalytic amination reactions.

@article{Ackermann2005GeneralAE,
  title={General and efficient indole syntheses based on catalytic amination reactions.},
  author={Lutz Ackermann},
  journal={Organic letters},
  year={2005},
  volume={7 3},
  pages={439-42}
}
[reaction: see text] Highly flexible and efficient syntheses of the indole backbone are presented starting from o-alkynylhaloarenes. These transformations proceed via a palladium- or a copper-catalyzed amination reaction and a subsequent cyclization reaction in good to excellent yields. Furthermore, a multicatalytic one-pot indole synthesis starting from o-chloroiodobenzene is viable using a single catalyst consisting of an N-heterocyclic carbene palladium complex and CuI. 

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