General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women

  title={General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women},
  author={Andrew J Petkus and Susan M. Resnick and Stephen R. Rapp and Mark A. Espeland and Margaret Gatz and Keith F. Widaman and Xinhui Wang and Diana Younan and Ramon Casanova and Helena Chui and Ryan T. Barnard and Sarah A Gaussoin and Joseph S. Goveas and Kathleen M. Hayden and Victor W. Henderson and Bonnie C. Sachs and Santiago Saldana and Aladdin H. Shadyab and Sally A. Shumaker and Jiu Chiuan Chen},
  journal={Alzheimer's \& Dementia : Translational Research \& Clinical Interventions},
  pages={118 - 128}
  • A. Petkus, S. Resnick, J. Chen
  • Published 10 April 2019
  • Psychology
  • Alzheimer's & Dementia : Translational Research & Clinical Interventions
Cognitive Reserve, Alzheimer’s Neuropathology, and Risk of Dementia: A Systematic Review and Meta-Analysis
CR protects against MCI and dementia progression above and beyond the effect of AD-related structural pathology and biomarkers, and underscores the importance of early- and mid-life factors in preventing dementia later.
The Risk of Dementia in Relation to Cognitive and Brain Reserve
The findings illustrate the importance of late-life over early-life reserve in understanding the risk of dementia, and show the need to study CR and BR conjointly.
The Paradoxical Effect of Living Alone on Cognitive Reserve and Mild Cognitive Impairment among Women Aged 60+ in Mexico City
Women living alone in this study had a more robust cognitive framework and had built their own support networks, and was an independent factor associated with a lower probability of displaying mild cognitive impairment and a higher probability of showing high cognitive reserve.
The importance of social support, engagement in leisure activities, and cognitive reserve in older adulthood
Evidence is presented that engagement in leisure activities may mediate the protective association between higher social support on a slower decline in executive function over a 6-year period, which may be important for delaying the onset of clinical ADRD.
Sociodemographic, Lifestyle, Physical, and Psychosocial Determinants of Cognitive Reserve
This study found that current smoking, diabetes mellitus, and depressive symptoms were associated with a lower cognitive reserve, whereas more alcohol use was associated with with a higher Cognitive reserve, but with clear differences between men and women.
Psychological correction of mild cognitive impairments in the elderly
Recommendations were developed to use the psychological correctional program by psychologists, clinical psychologists working with the elderly, as well as for the people of this age to maintain their cognitive functions within the individual norm and their relatives.
Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition
The present review attempts to synthesize available literature linking lifestyle modification to neurocognitive changes, outline putative mechanisms of treatment improvement, and discuss discrepant trial findings to improve understanding of individual neuroc cognitive differences in response to lifestyle modification.
Neurotherapeutics of the Aging Brain: Complexity Meets Complexity
A wide range of articles bring the reader into the latest developments in the field of healthy brain aging, to create a coherent narrative of what appear to be isolated strands, and combine multiple physiologic changes associated with myriad disease states into efficient and doable interventions over wide populations.


Quantifying Cognitive Reserve in Older Adults by Decomposing Episodic Memory Variance: Replication and Extension
The residual reserve variable was associated with higher reading ability, lower likelihood of meeting criteria for mild cognitive impairment, lower odds of dementia conversion independent of age, and less decline in language abilities over 3 years, and moderate the negative impact of memory variance explained by brain pathology on language decline.
Educational Attainment, MRI Changes, and Cognitive Function in Older Postmenopausal Women from the Women's Health Initiative Memory Study
Higher educational attainment was associated with a delay in diagnosis of dementia/MCI in the face of a growing neuropathological load, and higher education predicted better cognitive performance.
Measuring cognitive reserve based on the decomposition of episodic memory variance.
The results show that the current level of reserve, as measured by this decomposition approach, modifies rates of conversion from mild cognitive impairment to dementia, modifying rates of longitudinal decline in executive function and attenuates the effect of brain atrophy on cognitive decline such that atrophy is more strongly associated with cognitive decline in subjects with low reserve than in those with high reserve.
Cognitive reserve
Network-Based Substrate of Cognitive Reserve in Alzheimer's Disease.
The hypothesis that CR impacts on neurodegenerative process in the early phase of AD only is supported, and fit with the existence of a "neural reserve", characterized by specific neural networks and their efficiency.
Cognitive Activities During Adulthood Are More Important than Education in Building Reserve
Results suggest that leisure cognitive activities throughout adulthood are more important than education in determining reserve, and Discrepancies between cognitive activity and education may be informative in estimating late life reserve.
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
Results suggest that cortical atrophy is an index of disease severity in both AD and subcortical cerebrovascular brain injury and consequently predicts faster progression and Hippocampal volume may index disease severity and predict progression in AD.
MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer’s disease
Results suggest that cognitive impairment associated with subcortical ischemic vascular disease is primarily a result of associated hippocampal and cortical changes.
Memory function in very early Alzheimer's disease
A measure of learning with facilitation of performance using cues appears to be the best discriminator at detecting very mild AD.