General and Specific Receptor Tyrosine Kinase Signaling Mechanisms Revealed by Analysis of Chimeric EGFR and IR Family Receptors

@inproceedings{McCabe2015GeneralAS,
  title={General and Specific Receptor Tyrosine Kinase Signaling Mechanisms Revealed by Analysis of Chimeric EGFR and IR Family Receptors},
  author={Jacqueline M McCabe},
  year={2015}
}
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We point out an underappreciated dimer in the crystal structure of the related Insulin Receptor (IR) with Insulin bound that allows direct comparison with unliganded IR and suggests a mechanism by which ligand regulates IR/IGF1R activity. We test this… CONTINUE READING

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