General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

@article{Franks2008GeneralAF,
  title={General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal},
  author={Nicholas P. Franks},
  journal={Nature Reviews Neuroscience},
  year={2008},
  volume={9},
  pages={370-386}
}
  • N. Franks
  • Published 1 May 2008
  • Biology
  • Nature Reviews Neuroscience
The mechanisms through which general anaesthetics, an extremely diverse group of drugs, cause reversible loss of consciousness have been a long-standing mystery. Gradually, a relatively small number of important molecular targets have emerged, and how these drugs act at the molecular level is becoming clearer. Finding the link between these molecular studies and anaesthetic-induced loss of consciousness presents an enormous challenge, but comparisons with the features of natural sleep are… 

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